Chromium Picolinate is a combination of chromium and picolinate acid. Combined with exercise, it is commonly used to lose weight through reducing appetite, increasing metabolism rate and melting fats. This, however, has not been proved clinically. It is also believed to increase energy, life span, prevent acne and improve a person’s mood. Being considered a natural alternative to steroids, it is recommended to athletes. Chromium is found in fish, poultry, whole-grains, cheese and meat. It helps in the proper working of cells by improving the efficiency of insulin. Picolinate acid helps in the proper absorption of chromium. A combination of chromium picolinate and other supplements may be risky, hence professional advice should be sought before using it. Pregnant or nursing women should also be careful.

PEA (Phenylethylamine), which is also known as Beta-Phenylethylamine, is a supplement, which favors aggression and is supposed to raise mental alertness, focus, and ability to concentrate. It is believed to also promote energy. In clinical trials it has been observed that infusion of Beta-Phenylethylamine raises the extracellular dopamine count, furthermore inhibiting the dopamine transmitter DA neuron firings. An additional activity is seen through the Beta-Phenylethylamine modulation of noradrenergic transmissions. It is viewed as a stimulant, but the lack or disturbed amounts of PEA have been observed in people with attention deficit and the hyperactivity disorders, people suffering from depression, schizophrenia, migraine and phenylketonuria. The obvious antidepressant qualities are paired with the increased wakefulness, which may lead to difficulty falling asleep, but improve motivation when exercising or training.

Synephrine or oxedrine is a drug derived from bitter orange or Citrus aurantium. It is an aromatic compound with the systematic name 4-[1-hydroxy-2-(methylamino)ethyl]phenol which indicates that it has an attached hydroxyl group at para position and a methyl amino group at another position. It is not one of those compounds on which an extensive scientific study has been done. However, it has some positional isomers such as the neosynephrine as well as other compounds. Studies indicate that it could act as a Beta-3 adrenergic receptor which means that if taken as a supplement it enhances the breakdown of fat to release energy and also increases heat production in the muscles.

Vitamin B12 is a potent vitamin that needs only a little amount of dosage to work efficiently. It is sometime referred to as “cobalamin” because of its cobalt contents. It plays an important role in the production of protein from amino acids, maintenance of nervous system, growth and development, and in the production of deoxyribonucleic acid (DNA). It helps prevent anemia because it promotes the production and formation of healthy red blood cells. It also protects the myelin in the nervous system that enables them to function properly that promotes mental clarity, and prevent memory loss. It is also important in cell replication, and proper metabolism of energy.