Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Thermonex EF, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Diiodotyrosine, used by the thyroid hormones T4 and T3, Diiodotyrosine may help the thyroid gland to maintain proper function and help preserve lean muscle and supports the thyroid without suppressing TSH levels.

Evodiamine, an alkaloid extract from the Evodiae Fructus plant is known as Evodiamine. It has been referred to as a “hot nature” herb in Chinese literature and medicine. Based on animal studies, Evodiamine increases the natural fat burning rate and stimulates vanilloids for reduction of fat intake. It increases body temperature, influences the adrenal glands to secrete catecholamines and also affects the metabolism of certain drugs. Since it acts like a thermogenic and increases the overall temperature, more fat and calories are burnt due to its intake. This alkaloidal compound has anti obesity effects due to UCP1 (uncoupling protein 1) thermogenesis. In part, evodiamine can prevent diet induced obesity from developing further. It is available in the form of supplement or through Evodiae Fructus plant.

Green Tea Extract increases energy expenditure and affects fat oxidation, which therefore promotes weight loss by increasing the body's metabolism.

Iodotyrosone, which is a form of tyrosine with iodine added.

L-Tyrosine is a common amino acid and a para-isomer of tyrosine. It is deemed organic because of the carbon atom present and it is nonessential to survival, but works as a building block of protein. It is also viewed as a precursor of dopamine, which has several effects, like offsetting fatigue, mental and physical, as well as increasing the impression of well being. When the amino acid phenylalanine is broken down, L-Tyrosine can be won completely naturally. Besides being a precursor of the aforementioned neurotransmitter dopamine, L-Tyrosine is also deemed a precursor to some adrenal hormones, namely epinephrine and norepinephrine. In body building circles this supplement is popular to offset fatigue after a hard training or competition, but also to raise mental alertness while working out.

Naringin, which is a citrus flavanoid that is found in grapefruit. Naringin is commonly used in energy supplements as it may extend the duration of the effects of caffeine.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Synephrine is an active compound that may be found in the fruit called Citrus aurantium or Zhi Shi in Chinese. Its chemical composition is similar to ephedrine and pseudo-ephedrine that may be found in most over the counter cold or allergy medications, weight loss and energy supplements. Unlike ephedrine, Synephrine is considered to be semi-selective sympathomimetic that targets tissues such as fats instead of the heart. It also helps the metabolism without the negative effects of ephedrine to the nervous system. It also increases the energy level, helps the body burn fat and promotes weight loss. It also aids the body to increase the quickness of caloric expenditure.

Yerba Matte contains natural nutrients and antioxidants. It contains 11 polyphenol, which are a group of phytochemicals. Phytochemicals are effective antioxidants and are thought to show anti-cancer effects in mammal by making strong natural defenses of an organism and protecting it against cellular destruction. Yerba Matte leaves also have saponins, which are phytochemicals that help induce the immune system and assist the body in protection against ailment. They have important anti-inflammatory properties. Yerba Matte can also prevent oral cancer. Research has shown it contains 90 percent more nutrients, which boost metabolism, than green tea. Some of the vital antioxidant enzymes in the body are also stimulated by Yerba Matte.