Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Thermonex EF, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Diiodotyrosine, also known as DIT, is a drug used to treat hyperthyroidism and is often included in dietary supplements designed to increase the metabolism and burn fat. It is considered a synthetic anti-thyroid agent that is used to decrease the amount of hormones the thyroid produces. In some cases it produces a response more quickly than radioactive iodine therapy while not causing the thyroid gland permanent damage. Possible serious side effects of this drug are the suppression of bone marrow which can lead the patient to having a decreased number of blood leucocytes, bronchitis, hepatitis, jaundice, skin rashes, and/or syndromes that are similar to systemic lupus erythematosus.

Evodiamine is a chemical that is extracted from a particular species of plants that has been shown to reduce overall fat intake.

Green Tea Extract comes from green tea leaves and has been shown to be a very effective supplement for many common ailments ranging from minor to life threatening. Green tea extract is known for its strong antioxidant qualities, making it popular amongst those who take an active role in ensuring their good health. In fact, green tea extract has twenty times more antioxidants than the same portion of Vitamin C, another clouted supplement for health aficionados. In addition to antioxidants, green tea extract is effective at fighting carcinogens and inflammation. Green tea extract is best known for fighting cancer when combined with other methods, for reducing inflammation, and for encouraging overall good physical health.

Iodotyrosone, which is a form of tyrosine with iodine added.

L-Tyrosine is an amino acid taken to enhance the functions of the thyroid gland. It provides essential supplements to the body for fighting serious ailments. L-Tyrosine is a natural cure mainly for hypothyroidism and many other illnesses including protection of skin from the UV rays and depression. People suffering from hypothyroidism lack tyrosine and therefore do not respond to iodine supplements. Iodine supplements are of no use without tyrosine. Using L-tyrosine replaces vital amino acids which people having hypothyroidism lack. It produces thyroid hormones namely, norepinephrine, dopamine and epinephrine. L-tyrosine must be used by those who have a family history of under active thyroids and by those who have not got benefits from dieting efforts. L-tyrosine is taken in doses of 500mg 2 to 3 times everyday. People having high blood pressure must be cautious while taking this supplement.

Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It occurs naturally in all citrus fruits so it is also called citrus Naringin. It is used in medicine for its pharmacological effects such as an antioxidant and for blood lipid lowering. Research also shows that Naringin can be used for inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2. Its anti-cancer effects are also being studied by researchers. Naringin is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated to make naringin dihydrochalcone, which is used as a sugar-free sweetener 300 times sweater then sugar.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Synephrine is a drug that is deemed to selectively bind to and also activate alpha adrenergic receptors. Mainly used as a vasoconstrictor in asthma, glaucoma, circulatory failure and nasal congestion, this compound is currently propagated as a weight loss agent. The alleged function synephrine is providing include fat burning, energy level and metabolism increase and promotion of weight loss. Synephrine, also known as oxedrine, is the widely accepted replacement for ephedrine. The natural source of synephrine is the citrus aurantium fruit, better known as bitter orange. Bitter orange extracts, which contain synephrine, are known to stimulate the alpha-1 adrenergic receptor, thereby constricting blood vessels and increasing the heart rate as well as blood pressure, effecting in an increased energy use.

Yerba Matte, actually yerba maté, as it is called in Brazil, or Ilex paraguariensis in Latin, is a small tree or a shrub which can grow to fifteen meters. It is found naturally in South America, mainly in south of Brazil, Argentina, Paraguay, Uruguay and Chile. Foliage is evergreen, and the flowers are rather small, additionally there is a smallish fruit of red color. A tea like brewing in warm water, not boiling, is a popular drink in the native area, similar social gathering is common, akin to tea time practice in the United Kingdom. Yerba matte has several xanthines alkaloids which are related to caffeine, but although chemically identical to caffeine the mate xanthine cocktail provides different results, for instance it relaxes smooth muscle tissue and stimulates heart tissue. Yerba Matte is a potent ingredient in Thermonex EF.