Caffeine is extracted from coffee and tea during the process of decaffeination. Caffeine Anhydrous can be produced from dimethyl urea and malonic acid. It stimulates the central nervous system, enhancing the focus, concentration, and alertness, and warding off drowsiness. It is a mild diuretic and can also increase the metabolism. It increases the energy level and reduces fatigue. Aside from increasing mental alertness, it also helps in maximizing weight loss training. It stimulates the metabolism that helps the body to burn fat faster and uses the fat as energy. It also provides physical energy and delays the onset of fatigue.

Diiodotyrosine, used by the thyroid hormones T4 and T3, Diiodotyrosine may help the thyroid gland to maintain proper function and help preserve lean muscle and supports the thyroid without suppressing TSH levels.

Evodiamine has been used in Chinese medicine and by Chinese herbalists for centuries for weight loss purposes. It is an extract from a plant, Evodia or Tetradium, actually a tree genus of the family Rutaceae. The bee bee tree, as it is called besides Euodia and Evodia, provide a bioactive alkaloid that the Chinese have nicknamed Wu-Chu-Yu. This extract not only can interact with UCP1, a thermogenic protein, which as a consequence burns energy as heat, but also has shown in studies on mice to reduce the fat uptake. Evodiamine seems to increase the resting temperature of humans, whereby increased fat and calories are burned in order to supply the heat. Deemed a breakthrough in thermogenesis, evodiamine is subject of several clinical studies.

Green Tea Extract increases energy expenditure and affects fat oxidation, which therefore promotes weight loss by increasing the body's metabolism.

Iodotyrosone, which is a form of tyrosine with iodine added.

L-Tyrosine is a protein non-essential building block Although non-essential it is important for the structure of body proteins. It has a direct effect on neurotransmitters.

Naringin, which is a citrus flavanoid that is found in grapefruit. Naringin is commonly used in energy supplements as it may extend the duration of the effects of caffeine.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Synephrine is an ingredient that is obtained mainly from the fruit of a small citrus tree, the Citrus aurantium, also known as bitter orange, zhi shi and sour orange. Synephrine is viewed as the safer version of ephedrine, whereby the properties include weight loss, increased fat burning, raised metabolism, as well as boosted energy levels. With such properties, this drug became instantly popular with the weight loss and control circles, but also with the body building community, and is now used in Thermonex EF where fat burning and higher energy level properties are eagerly sought after. Initial research show stimulation of beta-3 receptors, whereby no increased heart rate or blood pressure was observed. It seems that synephrine induces lipolysis and stimulates similarly to caffeine. Some have also observed that synephrine suppresses appetite and increases the metabolic rate.

Yerba Matte contains natural nutrients and antioxidants. It contains 11 polyphenol, which are a group of phytochemicals. Phytochemicals are effective antioxidants and are thought to show anti-cancer effects in mammal by making strong natural defenses of an organism and protecting it against cellular destruction. Yerba Matte leaves also have saponins, which are phytochemicals that help induce the immune system and assist the body in protection against ailment. They have important anti-inflammatory properties. Yerba Matte can also prevent oral cancer. Research has shown it contains 90 percent more nutrients, which boost metabolism, than green tea. Some of the vital antioxidant enzymes in the body are also stimulated by Yerba Matte.